CytoChip Oligo SNP
In addition to detection of copy number imbalance at a high resolution, CytoChip Oligo SNP microarrays incorporate SNP calling to enable the detection of copy number neutral LOH/UPD (loss of heterozygosity/uniparental isodisomy) in the same assay.
BlueGnome supply two CytoChip SNP platforms for two applications, CytoChip Oligo SNP 4x180K and CytoChip Cancer SNP 4x180K.
CytoChip Oligo SNP is for constitutional applications and incorporates the ISCA (International Standard Cytogenetic Array) 4x180K design. High resolution arrayCGH information is gained from the 150,000 probe ISCA design, the remaining 27,000 SNP probes to provide approximately 10 Mb genome wide LOH detection. The 4x180K ISCA design reports the gene content of over 500 recognised disease regions while genome wide coverage, including subtelomeres and pericentromeres, supports detection of imbalances as small as 60 Kb.
Fully genotyped SNPRef reference DNA (male and female) for use with the CytoChip Oligo SNP microarrays is now available to order. The corresponding genotype files required for analysis are available for download.
Complementary BlueFuse software licenses deliver fully automated array processing, including sophisticated algorithms for the identification and reporting of regions of copy number imbalance alongside regions of LOH. All results are stored in a powerful SQL database through which regions associated with specific characteristics may be easily identified, confirmed, exported and shared with collaborators.
CytoChip Oligo SNP may be ordered in boxes of four slides, complete with gaskets, or as a pack complete with quality controlled labelling systems and Human COT DNA.
See also
Applications in developmental delay.
CytoChip ISCA for different ISCA platforms without SNP probes.
For Research Use Only. Not for use in diagnostic procedures
