ArrayCGH is used to investigate genomic copy number imbalance at a higher resolution than is possible by karyotyping and traditional CGH. CytoChips are high quality BAC microarrays, designed to improve detection of copy number variation associated with constitutional genetic disorders (for research use only). CytoChips are used in over 120 institutions in over 20 countries to deliver more information to cytogeneticists.
To see some examples of CytoChips in action, click here.
CytoChip V3 has been designed to deliver new standards of performance.
- More relevant information. Investigate subtelomeres at a median 250 Kb resolution, reliably detect mosaicism and examine 110 known genetic conditions at a median 100 Kb resolution. Screen the entire genome at half a megabase, a resolution optimised to detect pathogenic variants while minimizing polymorphisms.
- Easier interpretation. Advanced algorithms in BlueFuse Multi generate a detailed list of imbalances that can be easily examined for gene content and CNV frequency using DecisionTrack technology. DecisionTrack allows rapid, informed and audited decisions to be made on which imbalances are potentially pathogenic and which are probably benign. ISCN compliant reports can then be automatically generated with a single click.
- Simple validation. CytoChips are manufactured with clones from the widely validated Roswell Park Cancer Institute BAC library ensuring full ‘RP’ nomenclature is available for all results. Each clone on the CytoChip may be ordered as a labelled FISH probe to directly validate the physical location of results and to investigate parental samples.
- Flexible design. Two hybridization areas on each CytoChip offer the choice of dye swap designs or two samples per array dependent upon volumes, costs and sample quality.
- Informed support. Call BlueGnome’s support line for detailed assistance from trained laboratory personnel.
“When researching a 17p duplication sample our existing commercial array detected only 2 non-consecutive clones whereas the CytoChip showed 22 clones, in the same region, as being duplicated. This increase in probe density and enhanced performance greatly improves both the confidence and ease of interpretation of results.” Dr. Karen Swisshelm, Director of the Colorado Genetics Laboratory
“CytoChips are easy to use and interpret. We use them routinely to investigate copy number imbalance at high resolution.” Udo Koehler, Head of CytoGenetics, Medizinisch Genetisches Zentrum Munich
“CytoChips provide more relevant information, more rapidly, than can be achieved by karyotyping alone.” Marcel Nelen, PhD, Clinical Molecular Geneticist, Department of Medical Genetics, UMC Utrecht
